[pygtk] Using glade in large applications

[steve george]

Saw the following text at http://www.exit1.org/Gtk2-Ex-FormFactory/

"RAD tools like Glade are fine for small applications but not if you 
want to have a consistent look and feel in bigger and modular applications"

Got me wondering, .. how do you all feel about using Glade for large 
scale applications?

Any other recommendations for 'frameworks or other' that help large 
scale python application development?

(Just started reading kiwi documentation, so already looking at that)

Steve