pygtk all in one installer for win has some problem. use gtk2-runtime-2.12.3-2007-12-16-ash.exe pygtk-2.10.6-1.win32-py2.5.exe pycairo-1.2.6-1.win32-py2.5.exe pygobject-2.12.3-1.win32-py2.5.exe and it is ok.