I've used MacPorts. I've installed pyGTK: sudo port -v install py26-gtk I've copied the module to have a chance to run it by typing "python": cp /opt/local/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/pygtk.py /System/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/pygtk.py Thanks for your help.